Supplements for the paper

Human Biology  Vol.  No.  pp.

Selection on the Human Bitter Taste Gene TAS2R16 in Eurasian Populations

Supplement Table. 

The long range haplotypes defined by all the 55 SNPs


Color figures:

Figure 1. Spacing and molecular positions of the markers typed.
The rs numbers can be used to retrieve the allele frequencies in ALFRED ( Gaps in the numbering and associated positions indicate the borders of the genes.


Figure 2. Haplotype diversity of TAS2R16 among the global populations.
The SNPs forming the core haplotypes are rs1357949, rs846664, rs702424, and rs9691345. (A) Haplotype frequencies of the world populations. The haplotype frequencies are also in ALFRED ( (B) Shortest tree of the haplotypes defined using Network with all 55 typed SNPs. The four SNP haplotypes are marked in the tree and color coded as in part A.


Figure 3. Evolutionary relationships among the core 4-SNP haplotypes in Figure 2.
The solid arrows stand for the likely historical accumulation of mutations, and the dotted lines indicate possible recombinations. The four SNPs are those in Figure 2, in the same order.


Figure 4. EHH and REHH values for the core haplotypes formed by rs846664 and rs702424.
We combined the populations with similar core haplotype frequencies (examined by Fisher’s Exact Test) to make the chart clear. The region abbreviations are the same as those in Figure 2A.


Figure 5. Reference frame of REHH-Haplotype frequency (A) and LREHH-Haplotype frequency (B).
Curve m was estimated based on all of the REHH values of the core haplotypes other than TC, and curve t was estimated based on the highest REHH values of the same haplotypes.


Figure 6. The geographic distribution of LREHH at 100kb downstream from the core haplotypes (A) and the Fay and Wu’s H statistics (B).
The values for the 45 populations at their geographic locations (red triangles) have been interpolated by SURFER using default parameters.