The gene collector
By Xu Wei 2003-11-17 Shanghai Daily
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Gathering DNA material from China's minority populations is a
massive undertaking. The daunting task needs to be done, according to doctoral
student Li Hui, as the resulting knowledge will have applications in biology,
history and sociology fields, reports Xu Wei
While his peers are enchanted by the picturesque landscapes in South China, Li
Hui is racing to collect invaluable genetic material among the country's
minority populations.
Li, a doctoral student with the center for anthropological studies at Fudan
University, is a sample collector and trying to breathe new life into
anthropological research.
Thus far, more than 30,000 pairs of hands have been studied. Based on palm and
skin lines, Li can quickly tell the origins of most Chinese people he meets.
Testing Li's unusual talent, I asked about my origins. He looks at my face, then
palms for several minutes.
``With combined features such as an oval face and spindly eyes, you probably
have a mixed origin from Tibet, south Jiangsu Province and north Zhejiang
Province,'' smiles Li, 26, by no means a fortune-teller. Yet his familiarity
with one's origin is astounding. He's correct.
And that's why Li jokes that his brain functions like illustration software
FoxPro. However, Li's ingenious brain is more than a database.
Awarded the Mayor's Prize for Scientific Innovation Amongst Youngsters by
Shanghai Mayor Han Zheng in August, Li's creativity and diligence have also
earned him the first prize of the Challenge Cup National Competition of
University Students' Science and Technology in 1999 and the Chun-Tseng Scholar
title in 2000. Though surrounded with such accolades, Li insists on continuing
with his work.
With the guidance of Jin Li, dean with School of Life Sciences at Fudan
University, a group of faculty members and students are sparing no effort to
understand the historical migration routes of the Asia-Pacific people. If
successful, the project could have wide applications in other areas of study
including biology, history and sociology.
Li is responsible for the sample collection in South China while colleagues are
on a similar mission in other areas of the country. After cautiously comparing
the DNA information acquired from hair and blood samples, and consulting
relevant materials, he can illustrate the delicate differences and relations
among varied ethnic groups and make a rough inference of their origins.
Back in 1997 that a letter written by Tan Jiazhen, a renowned biologist with
Fudan University, unexpectedly inspired Li's project. In Tan's letter to Jiang
Zemin, then China's president, Tan expressed deep concern about the dwindling
gene pool of China's minority peoples.
In reply, Jiang quoted an old Chinese saying, ``A man without distant care must
have near sorrow.'' With the government's support, Li, a student of Tan's,
gathered like-minded classmates and began his first trip to Xishuangbanna, a
scenic spot in Yunnan Province.
``On seeing the various ethnic minority groups there, I was deeply attracted by
their diverse palm lines and genetic characteristics,'' says Li. ``From then on,
my passion is tightly entwined with a whole new gene world.''
Nevertheless, sample collection is difficult and time consuming. It has also led
to several unexpected risks. Yet long treks up mountains and through thick
forests to reach remote villages have not dissuaded Li. He shrugs off such
fears.
``I ran across a mud-rock flow during my trip to the Guangnan County of Yunnan
Province in 2000,'' Li says. ``It was luck that I won the drastic race against
the rolling rocks. I have never run so fast in my life.''
Li also suffers from various allergies. Both Guangdong and Guizhou provinces
activated his eczema. Li persisted even when his body was covered with swollen
sores.
But he has a few tricks and tips for dealing with the jungle. Li happily
displays his ``weapons'' -- a package of salt to stop bloodsucking leeches and
garlic to strengthen his immune system against viral infections. The hardships
don't end there though, he has even slept in caves.
Risky and arduous as it is, the doctoral student enjoys the work. He takes
delight in talking about the amusing cultural differences.
``Take the Tai people, or the Dai minority people, and the Mien people, or the
Yao minority people, as an example,'' Li smiles. ``With a similar thinking mode,
I find it easy to communicate with Tai people, who are pragmatic and cooperative
with my work. The Mien people, though friendly, find continual toasts and feasts
more important. When they are drunk, it's a good chance for me to collect
samples, of course with their previous permission.''
The fundamental research of Li and his group is also affiliated with the grand
project of national gene group studies, a new push for the country's future
development. With increasing importance attached to genetic research, China is
investing heavily in life sciences, biotechnology and gene therapy research.
``To avoid making unilateral analysis and conclusions, sample collection is
basic and indispensable work,'' says Lu Daru, professor of the School of Life
Sciences with Fudan University. ``Based on the fundamental information acquired
from Li and his fellows, rough migration routes of each people will appear and
their genetic characteristics will also be well understood.''
And with that great mission in mind, Li, once again sets off for his next sample
collection trip.
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