COM.on C.A.1:e9/67-68  Online published on Jun. 9, 2007.
doi:10.4236/coca.2007.11009
FOCUS
Debate on Roles of Genotyping and Sequencing in Genetic Research
 HE Yungang
Molecular genetic program, Stanford Research Institute International, Menlo Park, CA94025

ABSTRACT: Advances in DNA sequencing technology greatly reduced time and financial cost of sequencing-based genotyping. Some geneticists predicted that large-scale genotyping platforms would be vanished with arising of whole-genome sequencing strategy. This paper pointed out that whole-genome genotyping is still with advantages and will continue his role in future.
Key words: DNA sequencing; genotyping; haplotype block; HapMap project
Received: May 25, 2007  Corresponding: HeYunGang@gmail.com
　
　
《现代人类学通讯》第一卷e9篇 第67-68页 2007年6月9日网上发行
动态评论
遗传研究中的分型与测序之争
 何云刚
国际斯坦福研究所分子遗传项目组，美国 加州 门罗公园 94025

摘要：DNA序列测定技术的飞速进步，使利用测序方法进行基因型检测的成本和时间消耗大大降低。由此有人预测DNA分型很快将被序列测定所完全取代。本文从多个角度探讨了分型技术相对于序列测定技术仍然具有优势的原因。说明分型技术在以后一个相当长的时期内仍然不可能被序列测定完全取代。
关键词：DNA测序；基因分型；单倍域；Hapmap计划
收稿日期：2007年5月25日 联系人：何云刚 HeYunGang@gmail.com
全文链接 Full text: [PDF]

参考文献 References
1. Check E (2007) Time runs short for HapMap. Nature 447:242-243.
2. Illumina Inc. dna analysis solutions: snp genotyping. http://www.illumina.com/pages.ilmn?ID=39
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4. The International HapMap Consortium (2003) The International HapMap Project. Nature 426: 789-796.
5. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678.
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