COMonCA2007012

ABSTRACT: Samoan is an isolated population inhibiting in South Pacific for more than 3000 years. A consistent genetic background and a high linkage disequilibrium level are found through the analysis of Samoan genome. Genetic evidences are more supportive for the “Express Train” model of Polynesian origin. There are large differences in living style and incidence rates of various diseases between West Samoan and American Samoan. However, these two populations are genetically homogeneous. All these facts make Samoan to be a model population for complex disease studies.
Key words: West Samoan; American Samoan; Polynesian; Isolated population; Complex disease
Recieved: Jun.18,2007; Accepted: Jun. 24, 2007; Corresponding:xihuifeng@gmail.com

摘要：萨摩亚人群是太平洋上一个有3000年历史的隔离岛屿群体。对萨摩亚人基因组的研究表明它拥有比较单纯的遗传背景和高的连锁不平衡水平，并且支持波利尼西亚人群起源的“快车模型”。随着东西萨摩亚的分治，东西萨摩亚的生活饮食方式已经有了巨大的差异，很多疾病的发病率也有很大的差别，但是两者在遗传上仍然是一个统一的群体。所有这些都使得萨摩亚人群成为一个复杂疾病研究的良好对象。
关键词：西萨摩亚；美属萨摩亚；波利尼西亚；隔离群体；复杂疾病
收稿日期：2007年6月18日修回日期：2007年6月24日联系人：奚慧峰 xihuifeng@gmail.com

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