PAN Xuedong
MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433 China
Key words: Hutterite; Cohort; Asthma; Genetics
Recieved: Apr.14, 2009 Accepted: Apr. 24,2009 Corresponding: andrewalwaystry@gmail.com
《现代人类学通讯》第三卷e7篇 第68-71页 2009年5月5日网上发行
动态评论
哈特人群哮喘遗传学队列研究的启示
潘学栋
复旦大学现代人类学教育部重点实验室,上海 200433
评论文献:Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF Jr., Nicolae DL, Elias JA, Chupp GL (2008) Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 358:1682-1691.
Ober C, Hoffjan S (2006) Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 7:95-100.
Ober C, Thompson EE (2005) Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol 17:670-678.
摘要:芝加哥大学人类遗传学教授Carole Ober在她的哈特人群队列中所作的疾病遗传学研究被普遍赞赏,哮喘研究是其中最出色的部分。本文以她的哮喘研究为例,说明选择具有相对单纯背景的队列,合适的疾病定义和分类,必要的重复验证,以及分析基因和环境的交互作用是Ober做好哮喘遗传学研究的关键。
关键词:哈特教派; 队列; 哮喘; 遗传学
收稿日期:2009年4月14日 修回日期:2009年4月24日 联系人:潘学栋 andrewalwaystry@gmail.com
FOCUS ON
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF Jr., Nicolae DL, Elias JA, Chupp GL (2008) Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 358:1682-1691.
Ober C, Hoffjan S (2006) Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 7:95-100.
Ober C, Thompson EE (2005) Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol 17:670-678.
参考文献 References
1. Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C (2003) Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Hum Mol Genet 12:137-144.
2. Ober C, Elias S, Kostyu DD, Hauck WW (1992) Decreased fecundability in Hutterite couples sharing HLA-DR. Am J Hum Genet 50:6-14.
3. Ober C, Elias S, O'Brien E, Kostyu DD, Hauck WW, Bombard A (1988) HLA sharing and fertility in Hutterite couples: evidence for prenatal selection against compatible fetuses. Am J Reprod Immunol Microbiol 18:111-115.
4. Ober C, Bombard A, Dhaliwal R, Elias S, Fagan J, Laffler TG, Martin AO, Rosinsky B (1987) Studies of cystic fibrosis in Hutterite families by using linked DNA probes. Am J Hum Genet 41:1145-1151.
5. Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Jr., Nicolae DL, Elias JA, Chupp GL (2008) Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 358:1682-1691.
6. Ober C, Tsalenko A, Parry R, Cox NJ (2000) A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 67:1154-1162.
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