COM.on C.A.4:e14/89-95   Online published on Jul.13, 2010.
doi:10.4236/coca.2010.41014
REVIEW
The Relationship between Diseases and Heme Oxygenase-1 Polymorphisms

CHU Haiyan

MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433 China

ABSTRACT: Heme oxygenase-1(HO-1) is a key enzyme in the antioxidative metabolism, the expression of which is induced by various factors. In human cells, it affects antioxidants, anti-apoptosis, and cell proliferation regulation. Thus, it is closely related to a number of diseases, including ischemia/reperfusion injury, cancer, and diabetes. This study shows that there are three polymorphic sites in the promoter region of HO-1. Previous studies have focused on the GT repeat sequences, which are divided into S-type, M-type, and L-type, according to the length of repetitive sequences (S-type, with its protective polymorphic site, has higher activity than the others). However, results from different populations are not consistent, which may be due to the diversity of genetic factors found amongst different populations.

Key words:Heme oxygenase-1; Anti-oxidant; Gene; Polymorphism; Disease

Recieved: Jun.25, 2010   Accepted: Jul.12, 2010  Corresponding: chuhaiyan1987@163.com


《现代人类学通讯》第四卷e14篇 第89-95页  2010年713日网上发行

专题综述

血红素加氧HO-1及其多态性与疾病的关系

楚海燕

复旦大学生命科学学院,现代人类学教育部重点实验室,上海,200433

摘要:血红素加氧酶-1(HO-1)是抗氧化代谢中的一种关键酶,其表达受多种因素诱导,在细胞中发挥抗氧化、抗凋亡、调节细胞增殖等功能。其与缺血再灌注损伤、癌症、糖尿病等疾病密切相关。目前的研究发现HO-1启动子区存在三个多态性位点。对其中的GT重复序列的研究较多,可根据重复序列的长短分为S型、M型、L型,S型的启动子有更高的活性,在多种疾病中是保护性的多态性位点。然而,在不同人群中的研究结果并未得出完全一致的结论,可能是不同人群的遗传结构的差异导致了这一结果。

关键词血红素加氧酶-1;抗氧化损伤;基因;多态性;疾病

 

收稿日期: 2010年625日  修回日期: 2010年7月12日 联系人:楚海燕 chuhaiyan1987@163.com
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