CHU Haiyan
MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433 China
Key words:Heme oxygenase-1; Anti-oxidant; Gene; Polymorphism; Disease
Recieved: Jun.25, 2010 Accepted: Jul.12, 2010 Corresponding: chuhaiyan1987@163.com
《现代人类学通讯》第四卷e14篇 第89-95页 2010年7月13日网上发行
专题综述
血红素加氧HO-1及其多态性与疾病的关系
楚海燕
复旦大学生命科学学院,现代人类学教育部重点实验室,上海,200433
摘要:血红素加氧酶-1(HO-1)是抗氧化代谢中的一种关键酶,其表达受多种因素诱导,在细胞中发挥抗氧化、抗凋亡、调节细胞增殖等功能。其与缺血再灌注损伤、癌症、糖尿病等疾病密切相关。目前的研究发现HO-1启动子区存在三个多态性位点。对其中的GT重复序列的研究较多,可根据重复序列的长短分为S型、M型、L型,S型的启动子有更高的活性,在多种疾病中是保护性的多态性位点。然而,在不同人群中的研究结果并未得出完全一致的结论,可能是不同人群的遗传结构的差异导致了这一结果。
关键词:血红素加氧酶-1;抗氧化损伤;基因;多态性;疾病
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