COM.on C.A.4:e22/134-137
Online published on
Dec.13, 2010.doi:10.4236/coca.2010.41022
COM.on C.A.4:e22/134-137
Online published on
Dec.13, 2010.SHAN Zhiqiong
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433 China
ABSTRACT: The short tandem repeats (STRs) is a kind of unstable short nucleotide repetitive sequence which can be inherited. STRs distribute extensively in human genome. The high polymorphism and heterozygosity, low mutation rate, and convenience for detection make STRs a kind of widely used genetic marker. The examination methods for STRs were also well developed. Today, STRs are applied to gene mapping, linkage analysis, genetic diagnosis and prenatal diagnosis, molecular anthropology, individual identification and paternity identification in forensic sciences, organic transplantation, etc.
Key words: Short tandem repeats; Polymorphism; Genetic marker; Human biology
Recieved: Nov.23, 2010 Accepted: Dec.10, 2010 Corresponding: 09210700047@fudan.edu.cn
《现代人类学通讯》第四卷e22篇 第134-137页 2010年12月13日网上发行
专题综述
短串联重复序列在人类生物学中的应用
单志琼
复旦大学生命科学学院遗传工程国家重点实验室，上海200433
摘要：短串联重复序列是一种可遗传的、不稳定的短核苷酸重复序列，具有基因组中分布广泛、高度多态性、高杂合度、低突变率、检测简便快捷等优点。自开发利用以来，在检测方法及应用领域等方面都得到了不断的拓展，现已广泛应用于基因作图、连锁分析、基因诊断与产前诊断、分子人类学、法医学个体识别和亲子鉴定、器官移植等领域，是目前应用最广泛的遗传标记。
关键词：短串联重复序列；多态性；遗传标记；人类生物学
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