COM.on C.A.5:e12/63-69   Online published on Oct.31, 2011.
doi:10.4236/coca.2011.51012
REVIEW
Research Progress of Factors that Influence Longevity

Zuyun Liu, Lei Li, Jie Liu, Xiaofeng Wang

MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China

ABSTRACT: Regional longevity phenomenon has recently received much attention in the field. Experts who study regional longevity have explored a number of factors, including natural environment, lifestyle, and inheritance, as well as psychological states associated with this phenomenon. This paper reviews current research dedicated to factors that affect population longevity. We concluded that the following contribute to longevity: an environment with appropriate temperature and relative humidity; air and soil rich in oxygen anions and important microelements (e.g. manganese, zinc etc.); healthy life habits (e.g. quitting smoking, restricting drinking, drinking tea, and regular physical activity); eating small, frequent meals at a slow-pace; living on a diet of mainly vegetables and grains; balancing intake of meat and vegetables; consuming a low-calorie, low-fat, and high-vitamin diet; having a longevity family history; and maintaining an optimistic outlook.

Key words: longevity, factors that influence longevity, environment, living habits, dietary habits, inheritance

Recieved: Oct.10, 2011   Accepted: Oct.30, 2011  Corresponding: 11210700056@fudan.edu.cn


《现代人类学通讯》第五卷e12篇 第63-69页  2011年10月31日网上发行

专题综述

影响长寿的因素研究进展

刘足云, 李蕾, 刘杰, 王笑峰

复旦大学现代人类学教育部重点实验室,上海 200433

摘要:人群的区域长寿现象一直受到众多专家的关注,为此他们进行了大量长寿影响因素的探索,包括自然环境、生活方式、遗传及心理精神状态等。本文对目前长寿影响因素的研究进展进行了综述。明显有助于长寿的因素包括:环境中温度、相对湿度适宜,空气中具有较高的氧负离子,土壤中富有锰、锌等重要微量元素;养成戒烟、限酒、饮茶和坚持适量体力活动的健康生活习惯;少食多餐、细嚼慢咽,饮食以素、杂粮为主、荤素搭配,坚持低热量、低脂肪、高维生素的营养摄入;具有长寿家族史;保持良好乐观豁达的精神状态。

关键词长寿;影响因素;环境;生活习惯;食物消费;遗传

 

收稿日期:2011年10月10日  修回日期:2011年10月30日 联系人:刘足云 11210700056@fudan.edu.cn


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参考文献 References

1.徐大芳(2008)老化之因与长寿之道.中国民康医学 20:1348-1350.
2.森下敬一(1986)长寿学入门.东京:美土里书房.229,246,275.
3.朱志明,张雨林(1987)我国现代百岁老人的调查分析.老年学杂志 7(4):3-7.
4.曾尔亢,何慧德(1987)我国现代百岁老人的流行学研究.老年学杂志 7(4):7-9.
5.Cournil A, Kirkwood TB (2001)If you would live long, choose your parents well. Trends Genet 17:233-235.
6.Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE(1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352.
7.朱立达(2004)浅论《黄帝内经》中地理环境与人的关系.长春大学学报 14(2):92-94.
8.贾汉•沙比提(2010)长寿老人生活环境及饮食习惯与健康关系的研究进展.新疆医科大学学报 33:1024-1027.
9.蔡慧,付小竹,葛淼(2006)百岁老人与自然地理环境的关系.国外医学(地理分册) 27(2):89-92.
10.宗禾(2004)气候与健康.医药保健杂志 (10B):46-48.
11.程爱珍,梁玉红,谭斐,韦华红(2010)广西巴马长寿之乡气候环境特征分析.气象研究与应用 31(1):50-52.
12.覃卫坚(2003)广西旅游气候舒适度分析.广西气象 24(4):50-51.
13.刘旭辉,银建军,黄明秋(2007)巴马区域长寿现象的初步探讨.河池学院学报 27(2):46-50.
14.张钦鹏,姜学恩,杨志刚,郭述苏,薛慎伍,张新庆,梁恩皋,薛广波(1989)山东地区171例90岁以上长寿老人流行病学调查报告.老年学杂志 9(8):150-152.
15.贾汉•沙比提,马艳,王洪强,加孜那•托哈依,王茜,郑玉建(2010)新疆和田长寿老人健康与环境影响因素的研究.新疆医科大学学报 33:1009-1012.
16.邹忠,杨荣清,丁峰,黄标(2005)江苏省如皋市长寿现象与土壤环境关系研究初探.土壤 37(1):89-94.
17.尹方方,薛付忠,胡平(2010)沂蒙山区老年人长寿影响因素病例对照研究.中国公共卫生 26:405-406.
18.贾汉•沙比提,王洪强,吐尔逊江•买买提依明,刘金宝,克木巴提•吐尔德别克,古丽仙•哈力(2010)新疆和田地区60岁以上及长寿老人饮食及营养状况调查.新疆医科大学学报 33:1013-1016.
19.刘志坤,张魏丽,刘殿武(2006)高龄老人长寿因素研究进展.河北医科大学学报27(1):57-59.
20.滑冰,张新环(2010)人类长寿因素的探究.魅力中国 (3):148-149.
21.艾云良,关丽莉,王莉,贾氢,邱洪晟,白生义,许小丽,李翠芳(1998)新疆和田地区维吾尔族百岁老人长寿调查.西北国防医学杂志 19(2):119-120.
22.王文蕾(2007)四川省都江堰地区长寿老人营养状况评价D. 四川:四川大学营养与食品卫生.
23.张龙海(2002)神奇的蜂胶—人类生命健康的“紫色黄金”.知识纵横 (9):38-39.
24.谢琪,李西融,陈进超(2005)老年期营养素状况与长寿因素研究进展.华夏医学18(2):287-290.
25.Chen CX(2001)A survey of the dietary nutritional composition of centenarians. Chin Med J 114:1095-1097.
26. Fahy GM, West MD, Coles LS, Harris SB (2010) The Future of Aging: Pathways to Human Life Extension. New York: Springer. 367-438.
27.Le Bourg E (2010) A.V. Everitt, S.I.S. Rattan, D.G. Le Couteur, R. de Cabo (eds): Calorie restriction, aging and longevity. Biogerontology 11:731-732.
28.Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, Metter EJ(2002)Biomarkers of Caloric Restriction May Predict Longevity in Humans. Science 297:811.
29.Mehta LH, Roth GS(2009)Caloric Restriction and Longevity: The Science and the Ascetic Experience. Ann NY Acad Sci 1172:28-33.
30. Roth GS (2005) The Truth about Aging: Can We Really Live Longer and Healthier? Port Orchard, WA: Windstorm Creative Ltd.
31.McCay CM, Crowell MF, Maynard LA(1935)The effect of retarded growth upon the length of the life span and ultimate body size. J Nutr 10: 63-79.
32. Weindruch R,Walford RL (1988) The Retardation of Aging and Disease by Dietary Restriction. Springfield ,IL: Charles C Thomas Pub Ltd.
33.Le Bourg E(2010)Predicting whether dietary restriction would increase longevity in species not tested so far. Ageing Res Rev 9:289-297.
34.Willcox DC, Willcox BJ, Todoriki H, Curb JD, Suzuki M(2006)Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology 7:173-177.
35.陶国枢,张玲,张湘英,董仲勋,唐佐怡,赵福玲(1987)北京市303名90岁以上长寿老人流行病学调查.中国人民解放军军医进修学院学报 8:306-308.
36.俞经龙(2004)影响人类健康长寿的诸多因素及其解析.临床医学与亚健康 1:35-36.
37.吴雄芳,苗新普,陈志斌,王志英(2009)海南省百岁老人长寿因素的分析.中国老年学杂志 29:1676-1677.
38.夏建锋(1999)上海市116名百岁老人长寿因素的调查.上海第二医科大学学报19(2):165-167.
39.Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T(2001)A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.Proc Nat Acad Sci USA 98:10505-10508.
40.Cutler RG, Mattson MP(2001)Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev 122:895-898.
41.Sato A, Nakada K, Akimoto M, Ishikawa K, Ono T, Shitara H, Yonekawa H, Hayashi J (2005) Rare creation of recombinant mtDNA haplotypes in mammalian tissues. Proc Natl Acad Sci USA 102:6057-6062.
42.Alexeyev MF,Ledoux SP,Wilson GL(2004)Mitochondrial DNA and aging. Clin Sci 107:355-364.
43.Lanza IR, Nair KS(2010)Mitochondrial function as a determinant of life span. Pflugers Arch 459:277-289.
44.Lenaz G, D'Aurelio M, Merlo Pich M, Genova ML, Ventura B, Bovina C, Formiggini G, Parenti Castelli G(2000)Mitochondrial bioenergetics in aging. Biochim Biophys Acta 1459:397-404.
45.Shigenaga MK, Hagen TM, Ames BN(1994)Oxidative damage and mitochondrial decay in aging.Proc Natl Acad Sci USA 91:10771-10778.
46.Barja G, Herrero A(2000)Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J 14:312-318.
47.Santoro A, Salvioli S, Raule N, Capri M, Sevini F, Valensin S, Monti D, Bellizzi D, Passarino G, Rose G, De Benedictis G, Franceschi C(2006)Mitochondrial DNA involvement in human longevity. Biochim Biophys Acta 1757:1388-1399.
48.Tanaka M, Gong JS, Zhang J, Yoneda M, Yagi K (1998) Mitochondrial genotype associated with longevity. Lancet 351:185-186.
49.Ivanova R, Lepage V, Charron D, Schächter F (1998) Mitochondrial genotype associated with French Caucasian centenarians. Gerontology 44:349.
50.De Benedictis G, Rose G, Carrieri G, De Luca M, Falcone E, Passarino G, Bonafe M, Monti D, Baggio G, Bertolini S, Mari D, Mattace R, Franceschi C (1999) Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 13: 1532-1536.
51.Ross OA, McCormack R, Curran MD, Duguid RA, Barnett YA, Rea IM, Middleton D (2001)Mitochondrial DNA polymorphism: its role in longevity of the Irish population. Exp Gerontol 36: 1161-1178.
52.Niemi AK, Hervonen A, Hurme M, Karhunen PJ, Jylhä M, Majamaa K (2003) Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum Genet 112:29-33.
53.Chen YS, Torroni A, Excoffier L, Santachiara-Benerecetti AS, Wallace DC (1995) Analysis of mtDNA variation in African populations reveals the most ancient of all human continent-specific haplogroups. Am J Hum Genet 57: 133-149.
54.Pan H, Kong QP, Cheng YT, Lian SG, Yang J, Gao SJ, Xu LY, Zhang YP(2011)Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population. Exp Gerontol 46:511-515.
55.Rose G, Passarino G, Franceschi C, De Benedictis G(2002)The variability of the mitochondrial genome in human aging: A key for life and death? Int J Biochem Cell Biol 34: 1449-1460.
56.Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT (2010) Genetic Signatures of Exceptional Longevity in Humans. Science 333:404.
57.Pezzotti A, Kraft P, Hankinson SE, Hunter DJ, Buring J, Cox DG(2009) The Mitochondrial A10398G Polymorphism, Interaction with Alcohol Consumption, and Breast Cancer Risk. PLoS ONE 4:e5356.
58.Mueller EE, Eder W, Ebner S, Schwaiger E, Santic D, Kreindl T, Stanger O, Paulweber B, Iglseder B, Oberkofler H, Maier R, Mayr JA, Krempler F, Weitgasser R, Patsch W,Sperl W, Kofler B (2011) The Mitochondrial T16189C Polymorphism Is Associated with Coronary Artery Disease in Middle European Populations. PLoS ONE 6:e16455.
59.Fadini GP, Ceolotto G, Pagnin E, de Kreutzenberg S, Avogaro A(2011)At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways. Aging Cell 10:10-17.
60.Kivisild T, Tolk HV, Parik J, Wang Y, Papiha SS, Bandelt HJ, Villems R(2002)The Emerging Limbs and Twigs of the East Asian mtDNA Tree. Mol Biol Evol 19:1737-1751.
61.Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky JM, Beal MF, Davis RE, Howell N(2002)Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet 70: 1152-1171.
62.Kong QP, Yao YG, Sun C, Bandelt HJ, Zhu CL, Zhang YP(2003)Phylogeny of East Asian mitochondrial lineages inferred from complete sequences. Am J Hum Genet 73: 671-676.
63.Silva WA Jr, Bonatto SL, Holanda AJ, Ribeiro-Dos-Santos AK, Paixão BM, Goldman GH, Abe-Sandes K, Rodriguez-Delfin L, Barbosa M, Paçó-Larson ML, Petzl-Erler ML,Valente V, Santos SE, Zago MA(2002)Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America. Am J Hum Genet 71:187-192.
64.潘尚领,陈晶,尹瑞兴,刘承武,黄龄瑾,陈文成,罗晓秋,陈进超,黄必冠,罗毅(2006)线粒体DNA单倍型与广西壮族自治区巴马地区长寿的关联.中华老年医学杂志 25:362-363.
65.Cai XY, Wang XF, Li SL, Qian J, Qian DG, Chen F, Yang YJ, Yuan ZY, Xu J, Bai Y, Yu SZ, Jin L(2009)Association of Mitochondrial DNA Haplogroups with Exceptional Longevity in a Chinese Population. PLoS ONE 4:e6423.
66.Ren WH, Li XH, Zhang HG, Deng FM, Liao WQ, Pang Y, Liu YH, Qiu MJ, Zhang GY, Zhang YG(2008)Mitochondrial DNA haplogroups in a Chinese Uygur population and their potential association with longevity. Clin Exp Pharmacol Physiol 35:1477-1481.
67.Perls T (2002) Genetic and environmental influences on exceptional longevity and the AGE nomogram. Ann NY Acad Sci 959:1-13.
68.Benn M, Schwartz M, Nordestgaard BG, Tybjaerg-Hansen A(2008)Mitochondrial Haplogroups: Ischemic Cardiovascular Disease, Other Diseases, Mortality, and Longevity in the General Population. Circulation 117:2492-2501.

69.Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Nozawa Y, Lee HK, Tanaka M(2007)Mitochondrial Haplogroup N9a Confers Resistance against Type 2 Diabetes in Asians. Am J Hum Genet 80:407-415.
70.原野,王莉莉,张秋霞(2005)个人及家庭因素对彭山老人健康长寿的影响.市场与人口分析(增刊):140-145.
71.Krause N(1991)Stressful events and life satisfaction among elderly men and women. J Gerontol 46(2):S84-92.
72.孟卫平,张镜源,林光辉,魏红,杨丽华,陈小青,许燕敏(2000)老年人生活满意度与生存质量关系的探讨.中国行为医学科学 9(3):180-182.
73.海拉提•阿力地阿尔汗(2005)和田维吾尔族长寿老人生活环境及相关因素的研究D. 新疆:新疆医科大学公共卫生学院.
74.Idler EL,Benyamini Y(1999)Community studies reporting association between self-rated health and mortality:additional studies, 1995 to 1998. Res Aging 21:392-401.
75.Gagnon A, Mazan R, Desjardins B, Smith KR (2005) Post-reproductive longevity in a natural fertility population. PSC Discussion Papers Series 19(4) Article 1.
76.Beise J, Voland E(2002)Effect of Producing Sons on Maternal Longevity in Premodern Populations.Science 298:317.