Ting Wu
MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China
Key words: STAT, autoimmune disease, single nucleotide polymorphism, transcription factor
Recieved: Dec.7, 2011 Accepted: Dec.9, 2011 Corresponding: shanbenjiumei@sina.com
《现代人类学通讯》第六卷e6篇 第34-38页 2012年1月17日网上发行
专题综述
STAT4及其基因多态性与自身免疫性疾病的关系
伍婷
复旦大学 生命科学学院 现代人类学教育部重点实验室,上海200433
摘要:STAT4(信号转导因子和转录激活因子)是STAT转录因子蛋白家族的一个转录因子蛋白,它在Ⅰ型干扰素受体信号转导途径中发挥重要作用,同时在保护性免疫反应以及免疫介导疾病的炎症阶段是一个重要的媒介。另外,STAT4在细胞增殖、细胞因子介导的信号途径以及蛋白磷酸化等重要的生命过程中占有举足轻重的地位。目前,众多基因关联研究发现STAT4存在多个单核苷酸多态性位点,并且与多种自身免疫性疾病的发生、发展都存在密切关联。其不同的多态性位点在不同人群中存在一定程度上的差异,可能是由于不同人群遗传结构上的差异导致的。
关键词:STAT;自身免疫;单核苷酸多态性;转录因子
收稿日期:2011年12月7日
修回日期:2011年12月9日
联系人:伍婷
shanbenjiumei@sina.com
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