COM.on C.A.4:e21/129-133   Online published on Dec.9, 2010.
doi:10.4236/coca.2010.41021
REVIEW
Genetic and environmental factors of pathogeny: a population genetics view

ZHOU Weichen

MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433 China

ABSTRACT:  The factors of genes and environment are common causes of diseases. With theories of population genetics, we analyzed the possible causes of diseases on the aspects of population resources, familial inheritance, environment, interactions between genes and environment, physiological, biochemical, and cellular level disorders, respectively. The analyses may provide theoretical basis for genetic consulting, disease study, and health evaluation.

Key words: Population genetics; Disease genes; Environmental factors; Interaction of genes and environment; Susceptibility

Recieved: Nov.23, 2010   Accepted: Dec.8, 2010  Corresponding: arthurzhou10@gmail.com


《现代人类学通讯》第四卷e21篇 第129-133页  2010年12月9日网上发行

专题综述

群体遗传学角度分析疾病病因中的基因和环境因素

周玮晨

复旦大学现代人类学教育部重点实验室,上海200433

摘要:导致疾病的原因主要是基因因素和环境因素。本文运用群体遗传学知识,分别从人群群体角度、家族遗传角度、环境角度、基因与环境交互作用、生理生化及细胞等层面讨论疾病的发病原因,作出相应的分析解释。根据此分析对遗传咨询、疾病研究、健康诊断等提供理论基础。

关键词群体遗传学;致病基因;环境因素;基因与环境互作;易感性

 

收稿日期: 2010年11月23日  修回日期: 2010年12月8日 联系人:周玮晨 arthurzhou10@gmail.com
全文链接 Full text: [PDF]

参考文献 References

1.Daniel H (2000) Primer of Population Genetics. Sunderland:Sinauer.
2.Benjamin L (2004) Gene VIII. New York:Prentice Hall.
3.盛祖嘉, 沈仁权 (1988) 分子遗传学. 上海:复旦大学出版社.
4.Strachan T, Read AP, 孙开来译 (2007) 人类分子遗传学. 北京:科学出版社.
5.Price M (2009) Case Closed: Famous Royals Suffered From Hemophilia. Science now 8 October 2009.
6.原田正纯 (1995) 水俣病と世界の水银污染. 东京:实教出版.
7.Persico MG, Viglietto G, Martini G, Toniolo D, Paonessa G, Moscatelli C, Dono R, Vulliamy T, Luzzatto L, D'Urso M (1986) Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region. Nucleic Acids Res 14: 11-22.
8.潘尚领 (2007) 东亚及东南亚地区G6PD 缺陷的地域分布以及疟疾的正选择作用. 现代人类学通讯1:42-52.
9.Han XS, Han XM, Luo QL (2008) Cancer Incidence Patterns by Race and Sex in the United States, 1992-2005. Commun Contemp Anthropol 2:62-71.
10.Ober C, Elias S, Kostyu DD, Hauck WW (1992) Decreased fecundability in Hutterite couples sharing HLA-DR. Am J Hum Genet 50:6-14.
11.Zhang F, Lu C, Li Z, Xie P, Xia Y, Zhu X, Wu B, Cai X, Wang X, Qian J, Wang X, Jin L (2007) Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility. J Med Genet 44:437-444.